Practical science for a stubborn problem: infection.
Dr. Garcia is a translational pharmacologist and microbiologist. For more than a decade, his laboratory at Brown University and Rhode Island Hospital has developed antibiotic-independent ways to prevent infection in orthopedic surgery, work built around a silver carboxylate titanium-dioxide coating that reduces how bacteria adhere to implant materials such as PEEK, spinal rods, and titanium.
A second line of his work makes infection easier to see. His team built rapid, antibody-based visualization assays that detect bacteria and biofilm on surgical hardware, tissue, and synovial fluid, giving clinicians a faster read at the point where infection threatens recovery.
The through-line is practical. Get patients better answers, and better tools, against bacteria that grow more resistant to antibiotics every year. That work is reflected in an issued United States patent, an international patent application, and a further provisional filing.
Silver carboxylate-eluting titanium-dioxide polydimethylsiloxane coating inhibits multi-drug-resistant Acinetobacter baumannii and vancomycin-resistant Enterococcus faecalis on orthopedic trauma and spinal fusion materials
Drug-resistant bacteria that take hold on a surgical implant are very hard to treat. Dr. Garcia and his team coated common trauma and spinal implant materials with a silver carboxylate compound and showed it sharply reduced how two of the most stubborn resistant bacteria stuck to and grew on those surfaces, without relying on traditional antibiotics. It points toward implants that help resist infection on their own.
Read the paperSelected publications
- 2025 The cytotoxicity profile of silver carboxylate in a TiO2/polydimethylsiloxane matrix in osteoblasts, keratinocytes, endothelial cells, and skeletal muscle cells Surgical Infections
- 2025 An analysis of the chemical and physical properties of a silver carboxylate titanium-dioxide polydimethylsiloxane antimicrobial matrix on orthopedic implant materials Surgical Infections
- 2024 Silver carboxylate-TiO2/polydimethylsiloxane is a safe and effective antimicrobial with significant wound care potential OTA International
- 2022 Silver as an antibiotic-independent antimicrobial: review of current formulations and clinical relevance Surgical Infections
- 2022 Synergistic effects of silver carboxylate and chlorhexidine gluconate for wound care and prevention of surgical site infections by Cutibacterium acnes and MRSA Surgical Infections
- 2021 Silver carboxylate-doped titanium dioxide-polydimethylsiloxane coating decreases Cutibacterium acnes adherence and biofilm formation on PEEK The Spine Journal
- 2021 Silver carboxylate and titanium dioxide-polydimethylsiloxane coating decreases adherence of multi-drug resistant Serratia marcescens on spinal implant materials Spine Deformity
- 2020 Fluorescent-conjugated antibodies as rapid ex vivo markers for bacterial presence on orthopedic surgical explants and synovium: a pilot study Journal of Orthopaedic Research
- 2020 Analysis of growth and biofilm formation of bacterial pathogens on frequently used spinal implant materials Spine Deformity
- 2020 Early adherence and biofilm formation of Cutibacterium acnes on spinal implant materials The Spine Journal
- 2019 Commonly encountered skin biome-derived pathogens after orthopedic surgery Surgical Infections