Research

Practical science for a stubborn problem: infection.

Orthopedic infectionsAntimicrobial coatingsAntibiotic resistanceInfection diagnosticsBiofilms on implant materials

Dr. Garcia is a translational pharmacologist and microbiologist. For more than a decade, his laboratory at Brown University and Rhode Island Hospital has developed antibiotic-independent ways to prevent infection in orthopedic surgery, work built around a silver carboxylate titanium-dioxide coating that reduces how bacteria adhere to implant materials such as PEEK, spinal rods, and titanium.

A second line of his work makes infection easier to see. His team built rapid, antibody-based visualization assays that detect bacteria and biofilm on surgical hardware, tissue, and synovial fluid, giving clinicians a faster read at the point where infection threatens recovery.

The through-line is practical. Get patients better answers, and better tools, against bacteria that grow more resistant to antibiotics every year. That work is reflected in an issued United States patent, an international patent application, and a further provisional filing.

Featured work

Silver carboxylate-eluting titanium-dioxide polydimethylsiloxane coating inhibits multi-drug-resistant Acinetobacter baumannii and vancomycin-resistant Enterococcus faecalis on orthopedic trauma and spinal fusion materials

Drug-resistant bacteria that take hold on a surgical implant are very hard to treat. Dr. Garcia and his team coated common trauma and spinal implant materials with a silver carboxylate compound and showed it sharply reduced how two of the most stubborn resistant bacteria stuck to and grew on those surfaces, without relying on traditional antibiotics. It points toward implants that help resist infection on their own.

Read the paper

Selected publications

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